Cycloastragenol Overview

Cycloastragenol (CAG) also known as T-65 is a natural tetracyclic triterpenoid obtained from the Astragalus membranaceus plant. It was first discovered when Astragalus membranaceus extract was being evaluated for its active ingredients with anti-aging properties.

Cycloastragenol can also be derived from Astragaloside IV via hydrolysis action. Astragaloside IV is the major active ingredient in Astragalus membranaceus herb.  Although Cycloastragenol and Astragaloside IV are similar in their chemical structure, cycloastragenol is lighter in molecular weight than Astragaloside IV. Consequently, Cycloastragenol is more efficient due to high bioavailability and thus high metabolism of cycloastragenol. The high metabolism of cycloastragenol is noted in the intestinal epithelial via passive diffusion.

The astragalus herb have been used as a Chinese traditional medicine for centuries and is also being used today. Astragalus plant has been used due to its beneficial effects including anti-bacterial, anti-inflammatory as well as ability to enhance immunity.

CAG is indicated as an anti-aging compound that boosts the activity of the enzyme telomerase and wound healing. It is currently the major compound known to induce telomerase in humans, thus a great prospect supplement for further development.

Cycloastragenol is identified as telomerase activator, that plays role of increasing the length of telomeres. Telomeres are protective caps composed of nucleotide repeats at the end of the chromosome. These telomeres become shorter after every cell division which results to cell senescence and degradation. Further, the telomeres could also be shortened by oxidative stress.

This extreme shortening of telomeres is associated with aging, death and some ag-related disorders. Fortunately, telomerase enzyme is able to increase the length of these telomeres.

Although there no extensive studies to prove the ability of cycloastragenol to extend lifespan, it is a promising anti-aging compound. It has been proved to eliminate the signs of aging including fine lines and wrinkles. CAG may also lower the threat of developing degenerative disorders such as Parkinson’s, Alzheimer’s, and cataracts.

Despite the many cycloastragenol health benefits, there are concerns that it could lead to cancer or accelerate cancer. However, some studies conducted with animal subjects report benefits of cycloastragenol without any incidence of cancer.

Cycloastragenol powder for sale is readily available online and can be purchased from the many well-known cycloastragenol suppliers.

Despite, the many cycloastragenol health benefits indicated, it is still a new member under studies. Furthermore, cycloastragenol side effects are not very clear, hence should be used with caution.

 

What is Cycloastragenol

Cycloastragenol

Cycloastragenol is a triterpenoid saponin compound derived from the root of Astragalus herb. Astragalus membranaceus plant has been used in Traditional Chinese medicine (TCM) for over 2000 years and still being used in herbal preparations.

The astragalus herb has been known for its ability to improve the immunity, protect the live, act as a diuretic as well as a possess other health properties such as anti-hypersensitivity, antibacterial, anti-aging and anti-stress benefits.

Cycloastragenol commonly known as TA-65 but has also been referred to as Cyclogalagenin, Cyclogalegenin, Cyclogalegigenin, and Astramembrangenin. Cycloastragenol supplement is largely known as anti-aging agent, however, other cycloastragenol health benefits include enhancing immune system, anti-inflammatory and anti-oxidative properties.

Cycloastragenol and Astragaloside IV

Both cycloastragenol and Astragaloside IV occur naturally in the astragalus plant extract.  Astragaloside IV is the primary active ingredient in astragalus membranaceus, however, occurs in minute quantities in the root. The process of extracting these saponins, cycloastragenol and astragaloside IV, is usually difficult due to the high level of purification required.

While both cycloastragenol and astragaloside IV are derived from astragalus herb, cycloastragenol can also be obtained from astragaloside IV through hydrolysis process.

These two compounds have a similar chemical structure, however, cycloastragenol is lighter in molecular weight than astragaloside IV and is also more bioavailable.

Benefits of Cycloastragenol

i.Cycloastragenol and immune system

Cycloastragenol can help improve the immunity through boosting the proliferation of T lymphocyte. The ability of cycloastragenol supplement to activate telomerase enables it to stimulate DNA repair while leading o growth and elongation of telomere.

ii.Cycloastragenol and Anti-aging

Cycloastragenol anti-aging properties are the main interest of most research today. CAG has been indicated to delay aging in humans as well as reduce signs of aging such as wrinkles and fine lines. Cycloastragenol anti-aging activity is achieved through four different mechanisms. The cycloastragenol anti-aging mechanisms include;

Fighting oxidative stress

Oxidative stress occurs naturally when there is an imbalance between free radicals and antioxidant in the body. If not controlled, oxidative stress can accelerate the aging process as well lead to chronic conditions such as cancer, cardiac disorder and diabetes.

Cycloastragenol astragalus extract is an excellent antioxidant compound and also improves the capacity of the naturally existing antioxidants. This helps delay aging and also prevent the occurrence of age-related disorders.

Company Information:

Company Profile:

 1.Professional: More than 10 years chemical exporting experience.

 We have produced chemical more than fifteen years, 95% products are for export .

More than 10 years chemical exporting experience. Good and stabilized factory price.

 

2.Higher level &Strict quality control system.

We have ISO9001:2015,FDA, CE certificate.

 

3.Sample,COA, MSDS available.

 Before order, we can send the sample for your testing .

We ensure the quality is the same as bulk quantity.

 

4: H-NMR, HPLC, GC, LC-MS, GC -MS and many test spectrum provided to prove our good quality,

  Not only COA.

 

5:Factory Area:

6:Research center:

7:QC Team:

8:Warehouse and Packages

9:Certificates:

10:Professional Service:

  1:Any inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM / ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & Formulation development.
4.we provide Commercial Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.
5.Factory price.
6.Prompt delivery. We have good cooperation with many professional forwarders, We can send the products to you once you confirm the order.
7.We can accept various payment methods, L/C, T/T, D/A, D/P, O/A, paypal, etc., and we cooperate with Sinosure many years.

9. After-Sale Service:
   9.1:International Authorized Third-Party Test For The Products You Demand.
   9.2: 60 Days Warranty of quality of goods.

 

Packaging & Shipping:

Q1: How does your company to Pack 

A1:  1-10kg with double plastic bag inside,foil bag outside,finally with carton box.

      10-20kg with double plastic bag inside,carton box outside.

      >25kg double plastic bag inside,fiber drum outside.

      Net Weight: 25kgs/Drum Gross Weight: 28kgs/Drum

      Drum Size & Volume: 42cm× 42cm × H52cm, 0.08 m³/ Drum

 

Q2: which kind of transportation way could your company deliver 

A2: We can deliver products via DHL, TNT, EMS, Fedex etc.

   And for large quantity, Airway and Seaway is recommend way.

   And we could deliver the product to you as per your demand.

 

Shipping Terms Recommended
By Express Courier	By Air	By Sea
Suitable for under 50kg Fast: 3-7 days Door to door service, easy to pick up the goods	Suitable for more than 50kg Fast: 3-7 days Port to port,  professional broker needed	Suitable for more than 500kg Slow: 3-45 days Port to port,  professional broker needed

 

Q3: What is your standard package

A3: For stable solid products in the air, usually,we pack 20kg or 25kg per fiber drum depending on different products’ density.

For liquid stable products, the normal package is:170kg/drum, 200kg/drum, or IBC Tank.

The packing also can be according the customers’ requirements.

 

 

For example:

1:Shipping by Express Courier/Air:package details.

2:Shipping by Sea:Package details.

 

FAQ:

Q1: Could we get some samples
A: Yes, for some products,we can supply some free sample,

 Your company just need to pay for the shipping cost.


Q2: What kinds of documents will your company provide after our orders

A: we could provide: Commercial Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate. If your markets have any special requirements, let us know.

Q3: What’s your MOQ
A: To be honest, we do not have definite MOQ. The MOQ will be depend on the different products. For Some products which are not stable or will breakdown or low the assay easily in the air, the MOQ usually one minimum package, so that when you get the products, the products keep in the good and active state for your later usage.

Q4: How about delivery time after order
A: After our accountants check and confirm the payment. Our warehouse will send the goods to you Promptly. We have good cooperation with many professional forwarders, The shipping forwarders will try their best to deliver the goods to you ASAP.

Q5:What kind of payment method does your company accept

A: We can accept various payment methods, L/C, T/T, Paypal, etc., and we cooperate with Sinosure.

 

 

Q6: How long has your company been in this line

A: Our oldest manufacturing factory area started to produce products since 2002, 90% products are for exporting. We have been in exporting chemicals for more than 10 years. We could provide :Good and stabilized factory price.

 

Q7: How about your factories’ quality control system

A: Our company has Strict quality control system:We has passed through the ISO9001:2015 Quality System Certificate, and we also have FDA, CE certificates.